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Human colon adenocarcinoma stained with Ber-EP4 antibody using peroxidase-conjugate and DAB chromogen. Note the membranous staining of tumor cells
General & Epithelial Markers
Ber-EP4 Mouse Monoclonal
Epithelial cell adhesion molecule (EP-CAM) is an approximate 40 kDa transmembrane glycoprotein. In paraffin sections, the protein is detected with many antibodies lượt thích anti-Ber-EP4 and anti-MOC-31. EP-CAM (Ber-EP4) is normally expressed at the basolateral membrane of cells in the majority of epithelial tissues. It is not expressed in adult squamous epithelia, hepatocytes, myoepithelial cells, mesothelial cells or fibroblasts. EP-CAM is found in the large majority of adenocarcinomas of most sites (50-100%) in various studies; as well as neuroendocrine tumors, including small cell carcinoma. Renal clear cell carcinoma, renal oncocytoma and hepatocellular carcinoma stain in a minority of the cases, but papillary renal cell carcinoma, chromophobe renal cell carcinoma and cholangiocarcinoma stain with clone Ber-EP4 at a higher percentage. Basal cell carcinoma is anti-Ber-EP4 positive in almost all skin squamous carcinoma. EP-CAM can be of great help in the differentiating malignant involvement in the peritoneal and pleural cavities.
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC lớn 8ºC
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Immunogen:MCF-7 human breast carcinoma cell line
Product classification varies based on regulations of individual countries. Please tương tác your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
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